非正交码移键控和码索引调制算法

针对正交码移键控(code shift keying, CSK)误比特率(bit error rate, BER)性能下降和非正交码索引调制(non-orthogonal-code index modulation, N-CIM)未能充分利用扩频码自相关性的不足,提出一种非正交CSK和码索引调制(non-orthogonal-CSK-code index modulation, N-CSK-CIM)算法。发送端信息比特分为调制比特和扩频码映射比特；调制比特用来进行符号调制，映射比特映射为扩频码的索引和码相位索引。首先根据调制比特进行符号调制，然后利用映射比特映射的扩频码索引选择同一原始扩频码，并根据码相位索引进行码移键控产生新的扩频码，调制后的符号实部与虚部分别用这一新的扩频码进行扩频。仿真结果表明,在加性高斯白噪声(additive white Gaussian noise, AWGN)信道和瑞利衰落信道中,相同信噪比时, N-CSK-CIM算法的BER性能优于N-CIM算法和正交CSK算法。     

开展计算机辅助设计(CAD)教学提高学生工程实践能力

针对专业特点,开展计算机辅助设计教学与培训,以增强学生创新意识,培养应用现代技术能力.     

Many mechanisms, one entrance: membrane protein translocation into the nucleus

The inner nuclear membrane harbors a unique set of membrane proteins, many of which interact with nuclear intermediate filaments and chromatin components and thus play an important role in nuclear organization and gene expression regulation. These membrane proteins have to be constantly transported into the nucleus from their sites of synthesis in the ER to match the growth of the nuclear membrane during interphase. Many mechanisms have evolved to enable translocation of these proteins to the nucleus. The full range of mechanisms goes from rare autophagy events to regulated translocation using the nuclear pore complexes. Though mechanisms involving nuclear pores are predominant, within this group an enormous mechanistic range is observed from free diffusion through the peripheral channels to many distinct mechanisms involving different nucleoporins and other components of the soluble protein transport machinery in the central channels. This review aims to provide a comprehensive insight into this mechanistic diversity.     

中频反应磁控溅射制备具有光致亲水性TiO2薄膜

采用中频反应磁控溅射方法在玻璃表面制备了TiO2薄膜,为使薄膜获得理想的化学配比和较高的沉积速率,使用了等离子体发射光谱监控法(Plasma Emission Monitor,PEM)对溅射过程进行控制。对部分样品进行了退火处理。利用台阶仪测膜厚,X射线衍射(XRD)对薄膜的沉积速率及结构进行测试分析,并对部分沉积态和经过热处理的薄膜样品进行了透光性测试和光照实验。研究了温度,PEM工作点等不同工艺条件对薄膜光致亲水性等性能的影响。部分薄膜经过1h左右的紫外光照射,得到了很好的亲水性效果,其表面的水接触角达到了小于1°的水平。     

语言自主性学习理论评述

人本主义心理学认为学习者具有发展潜能的能力和动力，研究者应促进其个性发展和潜能发挥；社会认知学派通过所构建的研究框架确定学习自主性程度，采用五个维度描述自主学习状态，认为自主学习能力习得是将外部学习技能内化为个人能力的过程；信息加工理论指出完整意义上的自主学习过程经历四个阶段，还构建了自主学习内在机制；元认知理论认为循序渐进的发展过程直接影响自主性学习能力的发展。对各理论学派教育哲学理念进行全面梳理，利于研究者借鉴其成果，从而提出本土化之理论。     

巴尔虎人头面部形态特征的年龄变化

为研究巴尔虎人头面部形态特征随年龄增长而变化的规律,按照国际学术界规定方法,在内蒙古呼伦贝尔市新巴尔虎左旗测量了400例(男196例、女204例)巴尔虎成年人38项头面部指标,并计算了12项头面部体质指数,对巴尔虎人头面部形态特征的年龄变化进行了初步分析.结果表明(1)随年龄增长,巴尔虎人蒙古褶率下降,眼裂渐趋水平,鼻孔最大径趋于水平,眼色变浅,上唇皮肤部变高,红唇变薄.(2)巴尔虎人鼻宽、口裂宽、上唇皮肤部高度、容貌耳长、容貌耳宽与年龄呈正相关;眼外角间宽、唇高、红唇厚度、耳上头高与年龄呈负相关;头长、面宽、下颌角间宽、眼内角间宽、鼻长、鼻深、头围、面颊皮褶8项指标与年龄无相关.(3)形态面、头面高、鼻指数与年龄呈正相关,头长高、口指数与年龄呈负相关.说明巴尔虎人多数骨性头面部指标随年龄增长变化不大,而多数软组织指标随年龄增长变化明显.     

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition.     

How to halve ploidy: lessons from budding yeast meiosis

Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.     

手性药物拆分方法的研究

本通过对几种拆分手性药物的方法的列举，比较几种方法，详细介绍了几种方法的特点，以及它们的不同作用。各个方法中又列出了不同的线索，根据这些线索来研究这几种拆分的方法，它们的优缺点以及针对这些缺点的解决方法，最后给出了几个典型的用该方法的实验，以辨别它们的效用。     

高性能混凝干早期抗裂研究

为减小高性能混凝土早期开裂,利用非接触测量技术,测量了高性能混凝土早期自生及单面干燥条件下的收缩,研究了减缩剂、聚丙烯纤维等几种作用机理不同的物质对高性能混凝土早期自生及干燥收缩的影响.在此基础上,利用板式混凝土早期收缩开裂试验架,对高性能混凝土进行了约束试验,研究了减缩剂、减缩剂+聚丙烯纤维等对高性能混凝土早期抗裂的作用.结果表明:减缩剂、聚丙烯纤维、减缩剂+聚丙烯纤维及渗透结晶防水涂料均有减缩抗裂效果,其作用大小为渗透结晶防水涂料＞减缩剂＞减缩剂+聚丙烯纤维＞聚丙烯纤维.